Sentence examples for developmental blocks from inspiring English sources
Id2 and Id3 were found overexpressed in EPLMs expressing OBF1, and also to a lesser extent in large preB2 cells cells, the two stages where developmental blocks had been identified.
Our data indicate that even apparently selective developmental blocks can arise from lymphocyte-extrinsic, indirect effects and underscore the need to analyze lymphocyte development in animals that provide a healthy environment before concluding that a particular gene or cell type of interest impacts development of a functional immune system.
The Id2 and Id3 genes were both found deregulated in the microarray as well as in the qPCR validation experiments (Figs. 5 and 6); in particular, elevated expression was found in EPLMs and also in large preB2 cells, which are just the stages were the developmental blocks have been observed in BCS mice in vivo.
Though it is assumed that mutations in these vesicular trafficking factors promote tissue growth in part by removing developmental blocks to excess cell division, there is little direct evidence that links ept, vps25, or syx7/avl mutations to specific cell cycle transitions or to core components of the nuclear cell cycle machinery.
The earliest developmental blocks in oogenesis occurred in females knocked down for pbl, Hip14, eIF5, or CG9977.
In vivo deletion of Bak rescued the survival and developmental blocks of Mcl-1-deficient thymocytes at the double negative and single positive stages.
The developmental block of importin α7-deficient embryos coincides with the onset of ZGA.
The developmental block is associated with defects in thymocyte proliferation, survival, adhesion, and migration.
Furthermore, a strong developmental block was evident in the bone marrow with a dramatic accumulation of EPLMs accompanied with a deficit to progress to the preB1 stage.
These data suggest that Cdc42 is important for SP thymocyte migration but not adhesion and that defective migration may underlie the developmental block in Cdc42−/− thymocytes.
Indeed, the cells that succeed to pass this developmental block downregulate the transgene post-translationally, indicating that the level of OBF1 has to be low at this stage for proper B cell differentiation.
