Sentence examples for developmental barriers from inspiring English sources

While university spinoffs have become a well-accepted vehicle for regional economic dynamism, they face numerous developmental barriers associated with the unique academic context from which they are established.

Overall, summary of formulations/drug delivery systems contributing to improved clinical applications or overcoming developmental barriers of drug molecules is shown in Fig. 4. The various issues hindering development of molecules into drug candidate can be overcome by using drug delivery rout alternative to oral and parenteral applications.

It was surprising that overcoming the developmental barrier between ES cells and TS cells in Mbd3 −/− cultures did not involve activation of the canonical TE marker Cdx2.

Here we demonstrate that the Nucleosome Remodeling and Deacetylation (NuRD) co-repressor complex maintains the developmental barrier between embryonic and trophectodermal cell fates by maintaining transcriptional silencing of trophectoderm determinant genes in ES cells.

Our findings clarify the molecular nature of the developmental barrier between the embryonic and trophoblast cell fates, and establish a role for NuRD activity in specifying sites for de novo DNA methylation.

The molecular gatekeepers and mechanisms upholding the developmental barrier, which under normal conditions prevent immature INPs from dedifferentiating and assuming neural stem cell-like properties, are only now slowly beginning to be identified.

These include developmental plasticity, mechanical barriers, low molecular weight anti-microbial compounds named phytoalexins, pathogen-specific resistance genes and inducible pathogenesis-related (PR) proteins.

Participants were queried regarding attitudes, social norms, and barriers to developmental screening.

Third, we took consideration of children's age, developmental needs and environmental barriers in designing intervention activities [ 26, 27].

While there are benefits of surveillance, there are also barriers to developmental surveillance achieving its potential positive impact.

The ongoing visits facilitated the development of a trusting relationship that permitted the parent educator to identify barriers to developmental progress previously unrecognized in the clinic.