Sentence examples for developmental barrier from inspiring English sources

It was surprising that overcoming the developmental barrier between ES cells and TS cells in Mbd3 −/− cultures did not involve activation of the canonical TE marker Cdx2.

Here we demonstrate that the Nucleosome Remodeling and Deacetylation (NuRD) co-repressor complex maintains the developmental barrier between embryonic and trophectodermal cell fates by maintaining transcriptional silencing of trophectoderm determinant genes in ES cells.

Our findings clarify the molecular nature of the developmental barrier between the embryonic and trophoblast cell fates, and establish a role for NuRD activity in specifying sites for de novo DNA methylation.

The molecular gatekeepers and mechanisms upholding the developmental barrier, which under normal conditions prevent immature INPs from dedifferentiating and assuming neural stem cell-like properties, are only now slowly beginning to be identified.

While university spinoffs have become a well-accepted vehicle for regional economic dynamism, they face numerous developmental barriers associated with the unique academic context from which they are established.

Overall, summary of formulations/drug delivery systems contributing to improved clinical applications or overcoming developmental barriers of drug molecules is shown in Fig. 4. The various issues hindering development of molecules into drug candidate can be overcome by using drug delivery rout alternative to oral and parenteral applications.

These include developmental plasticity, mechanical barriers, low molecular weight anti-microbial compounds named phytoalexins, pathogen-specific resistance genes and inducible pathogenesis-related (PR) proteins.

Our results imply that developmental states of intestinal barrier and AVL and DVB neurons may serve as a pivotal determinant for recovery response in TiO2-NPs exposed nematodes.

Automated systems will enable cognitive scientists to ask questions that are currently difficult to address, and will significantly lower the barrier for developmental neuroscience labs embarking on projects that require them to quantitatively characterize the neurobehavioral consequences of alterations in embryonic development pathways.

Non-communicable diseases is a barrier to developmental goals that include poverty reduction, health equity, economic stability and human security.

Tgm3 knockout mice exhibit an in utero developmental delay in skin barrier formation, but the cornified layer is normalized by the time of birth and the mice do not suffer from perinatal dehydration.