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The consideration of adverse effects of other toxicologic end points (e.g., reproductive, immunologic, neurologic, developmental) associated with low exposure levels is also becoming more of a reality (e.g., endocrine disrupters).
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The same degree and intensity of injury at different ages must be achievable to isolate specific developmental effects associated with injury or stress during a particular developmental period.
The evolution of developmental systems, associated with adaptive changes in morphology, may entail evolutionary change in the developmental constraints that they cause [ 2].
Cells grown in vitro are more accessible for study of the developmental processes associated with xylogenesis.
ncRNAs therefore make for attractive targets for novel therapeutics to address the developmental deficits associated with FASDs.
These tests are currently used to investigate developmental abnormalities associated with gene overexpression or gene targeting in mice.
An altered release of 5-HT at PD30 would suggest an early developmental change associated with prenatal malnutrition.
These results indicate that overexpression of the exo-glucanase gene brought about various developmental defects associated with modification of cell wall and enhanced saccharification in rice.
We showed that overexpression of rice exo-glucanase resulted in various developmental defects associated with modified cell wall and enhanced saccharification in rice.
However, the early embryonic lethality and severe developmental defects associated with cilia disruption has hindered progress in exploring cilia functions in late development or in adult tissues.
Villous immaturity for gestational age is a multifactorial developmental deviation associated with unexpected placental insufficiency, fetal hypoxia and term fetal death.
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