Exact(2)
A simplified version of the leukocyte recruitment cascade exemplified for neutrophils is displayed in Fig. 1 (developmental aspects are indicated by footnotes and discussed in the next chapter).
In view of the recent plethora of genome-wide association studies to understand the genetic architecture of quantitative traits, developmental aspects are often ignored, especially pleiotropy, epistasis, effect sizes of novel mutations and modularity of developmental pathways– consequently misleading many aspects of genetics.
Similar(58)
The dependence of quantitative resistance on developmental aspects is a frequently recognised phenomenon [ 18, 19, 65, 66].
Especially, things become more challenging when developmental aspects have to be added in studies with minors.
23 In these mice, bone cells could not respond to glucocorticoids from birth; thus, it is possible that developmental aspects might be relevant and subtle long-term alterations occur.
Their developmental, evolutionary, and pathological aspects are discussed.
Only a meta-analysis addressing developmental aspects will be able to pinpoint, if the effect of the FTO variants is more relevant for children or for adults.
For instance, developmental aspects might be important to consider with respect to the potential diagnosis of Depressive Episode with Short-Duration Hypomania that recently was included in the section for conditions for further study in DSM-V [ 78].
Several aspects are noteworthy.
He argues that research into measurement, phenotypic refinement, developmental aspects and genetics is required.
First, youth grow up; thus developmental aspects need to be taken into account when monitoring changes due to treatment.
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