For example, the degree of fluctuating asymmetry between paired adult structures has been assumed by many studies to be indicative of degree of developmental instability and integration [ 1- 3], even though few studies made the effort to investigate the developmental underpinnings of asymmetry [ 4- 6].
We demonstrate the use of pathprinting for retrieval of functionally matched samples from cross-platform expression databases, reconstruction of the blood developmental lineage across species, and integration of data from mouse experiments, human samples, and clinical studies to develop new prognostic indicators and drug targets in acute myeloid leukemia (AML).
However, how Nrps regulate Hh transduction at the molecular level remains unknown, which limits our understanding of developmental signal integration and hampers the development of Nrp-related therapeutics for Hh-related tumors.
Elucidation and integration of developmental biology into future models of biologic skin substitutes promise to restore complete anatomy and physiology, and further reduce morbidity from cutaneous wounds.
This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.
This article describes the development of the ASU program and the integration of developmental and family-centered care into the curriculum plan.
We think he is right to stress that this is an additional barrier to the integration of developmental and evolutionary biology.
AP2/ERF is a large family of TFs in plants, encoding transcriptional regulators with a variety of functions in the control of developmental and physiological processes including the integration of JA and ET signals [ 33].
Some examples include: cell fate determination in Arabidopsis flowers [ 8], model study of role proteins (CLV1, CLV2, CLV3 and WUS) in shoot apical meristem of Arabidopsis[ 9], integration of developmental and hormonal pathways in the Arabidopsis flower [ 10], and gene regulatory network models for plant development [ 11].
Müller (2007a, b) and Collins et al. (2007) listed seven approaches and aims of evo devo: The origin of developmental systems; The evolution of developmental systems; Modifications of timing and context of developmental processes; Environment development interactions; Maintenance of phenotypic variation; Origin of phenotypic novelty; and Integration of genetics and epigenetic mechanisms.
