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Because no developmental alteration was observed between 3 and 4 weeks of age, it seems to be likely that the postnatal development of Müller cells from β2−/−/γ3−/− mice is aborted at an early stage.
Phthalates have been associated with endocrine disruption and developmental alteration.
Interestingly, M2 was enriched for terms associated with chromatin modification, suggesting a developmental alteration of epigenetic regulation.
Ppα-DOX knockout mutants did not have a visible developmental alteration and were not compromised in the defense response.
Targeted disruption of Ppα-DOX did not cause a visible developmental alteration and did not compromise the defense response.
None of the studies described above examines the effects of developmental alteration of insulin signaling and the resulting increased storage of fat.
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To characterize lysosomes and histochemical function of granular Sertoli cells in developmental alterations.
The very antenatal factors causing prematurity may impact on developmental alterations, with implications caused by prematurity overlapping (Fig. 1).
This phenotypic plasticity is obtained by integrating external signals with internal, mainly hormonal, signals that regulate developmental alterations.
These findings indicate that irradiations with neon ions at 0.1 1.5 Gy on day 15 of gestation caused varied developmental alterations in offspring, and efficient dose leading to the detrimental effects seemed to be lower than that of X-rays.
Developmental alterations in endocannabinoid signaling in the adolescent brain may therefore be responsible for the drinking phenotype seen in this age group.
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