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The cellular mechanisms underlying the developmental actions of testosterone and estrogen to determine patterns of neuronal cell death, synaptogenesis and axon guidance are being identified.
By identifying transformational periods, critical events and developmental actions in the evolution of design, the analysis suggests that expert-centred, tool-centred, strategy-centred, and process-centred approaches to developing design are not optional methods but rather phases in the broader capability development process, which bases on the transforming object of the business activity.
The neurotrophin Nerve Growth Factor (NGF) [1], [2] was originally identified for its developmental actions, as a neurotrophic survival factor necessary for the development and differentiation of sympathetic and sensory neurons during embryogenesis.
Possibly developmental actions of LGI1 on dendritic and synaptic maturation contribute to epileptogenesis.
Equally important, the CPF effects displayed a critical period of sensitivity, indicating that these are specifically developmental actions (Meyer et al. 2004).
These data indicate that the GHR, which is expressed and competent during the time of the postnatal leptin surge, mediates the developmental actions of GH on ARH projections.
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The developmental action of Notch is highly pleiotropic, affecting a broad spectrum of tissues, cellular fates, and developmental events.
Positive feedback loops are commonly seen in developmental pathways, which keep a developmental action silent in fluctuating background signals but trigger a robust response upon real stimuli at the right time and place.
To our knowledge, this is the first demonstration that PFAAs do indeed have direct, developmental neurotoxicant actions and that they target specific events in neural cell differentiation.
The fact that there are stark differences in developmental neurotoxicant actions among otherwise similar PFAAs means that it is important to take developmental neurotoxicity into account in the design of future members of this class.
To better define the gene expression programs dependent only on developmental androgen actions, we analyzed gene expression profiles of fibroblasts derived from homologous embryonic structures: the labioscrotal swellings in 46, XY males (scrotum) and 46, XY females (labia majora).
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developmental initiatives
developmental steps
developmental interventions
advanced actions
evolutionary actions
preparatory actions
developmental determination
developed actions
developmental intervention
developmental procedure
assignment actions
developmental achievement
posting actions
allocating actions
developing actions
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