Because of optical, developmental, and genetic accessibility of neurons and their embryonic precursor cells, zebrafish are an excellent system for investigating how neural circuits give rise to behavior [130], [131], [132].
We observed clear developmentally dynamic patterns of chromatin accessibility surrounding two key developmental genes and two genes highly expressed in mature retina.
Uyehara, C. M. et al. Hormone-dependent control of developmental timing through regulation of chromatin accessibility.
We investigate the role of local chromatin accessibility in determining the developmental pattern of TcraTcrd locus variable gene segment recombination.
Developmental stage-specific regulation of transcriptional accessibility helps control V(D J or VJ recombination.
cisMEP collects the chromatin accessibility data for different developmental stages and hence provides the temporal behaviour of CRMs.
It followed a rigorous well defined developmental process, and provides user-friendly, accessibility and convenience to users [ 26].
Our DA is the first to our knowledge in neonatal care; it followed a rigorous well defined developmental process, and offers the ease, accessibility and convenience to users since it is web based.
These epigenetic changes reduce the silencing of the target genes and increase cellular plasticity by facilitating the accessibility of transcription factors to developmental regulators and easing the switch to new epigenetic states [ 21].
This gives a scope for modulating the expression of a few histone chaperones in order to respond to developmental and stress signals via altering chromatin accessibility at the target loci.
The transcriptional enhancers Edelta and Ealpha have been implicated as critical regulators that, in conjunction with other cis-acting elements, confer region-specific and developmental-stage-specific changes in gene segment accessibility within TCR alpha/delta locus chromatin.
