High risk of cervical insufficiency may result from developmental abnormality (abnormal collagen or diethylstilbestrol exposure), previous surgery (amputation or exconization), and laceration by previous transvaginal cerclage or cervical rupture.
RLF/INSL3 has been implicated in the regulation of testicular function: RLF/INSL3-knockout male mice exhibit cryptorchidism during fetal development because of a developmental abnormality in the gubernaculum, which results in abnormal spermatogenesis and infertility [ 3, 4].
In a detailed series of experiments, they show that there is a developmental abnormality of LCI that correlates directly with the abnormal behavior.
Amputation may be performed for several reasons including arterial disease, gross injury, tumours, and developmental abnormality, all more common in the legs than in the arms.
An important known risk factor is a developmental abnormality that consists of a failure of one or both testes to descend into the scrotum, which normally takes place around the time of birth.
Shed by the yolk sac and fetal liver, alpha-fetoprotein can be used to screen for neural tube defects such as anencephaly and spina bifida (developmental abnormality in which spinal cord is not fully enclosed).
The resulting seedlings reached maturity without any obvious developmental abnormality, except for the sterility expected from a 3n rice plant.
Cartilage-like nodules were demonstrated within the valve annulus region at all stages identifying a developmental abnormality preceding AVD.
At the other end of the spectrum, the same morphological discrepancy could also be considered a developmental abnormality of genetic origin.
Focal cortical dysplasia (FCD) is regarded as a developmental abnormality and it has a strong association with difficulty in treating epilepsy in both children and adults.
The aetiology of lymphangioma is poorly understood but is believed to be a developmental abnormality characterised by failure of lymphatic tissue to establish normal communication with regional lymphatic vessels, resulting in dilatation of the abnormal channels [11].
