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Genetic and/or environmental perturbations of the maternal physiology and behavior can lead to developmental abnormalities in the offspring that are manifested in adolescence of adulthood as mental and cognitive disorders.
Similar attenuation was observed with pharmacological inhibition of TP signaling in wild-type splenocytes, suggesting that reduced responsiveness was not due to subtle developmental abnormalities in the TP-deficient mice.
And when the team examined the brain tissue of the homozygous knockout mice, it found striking developmental abnormalities in the cerebellum, especially in the Purkinje cells, which are involved in fine motor control.
Further histological analyses were performed in Txnrd1-NS null mice to define the developmental abnormalities in the cerebellum.
There was no significant synergism of developmental abnormalities in the double mutants.
Additionally, the azidosugar and DIFO treatments did not result in any toxicity or developmental abnormalities in the treated embryos.
Similar(42)
The results of our study of the developmental abnormalities in these cohorts were previously reported [ 42].
Instead, it is likely that the tap habituation defect in rpm-1 mutants is a consequence of the developmental abnormalities in these animals.
RLF/INSL3 has been implicated in the regulation of testicular function: RLF/INSL3-knockout male mice exhibit cryptorchidism during fetal development because of a developmental abnormality in the gubernaculum, which results in abnormal spermatogenesis and infertility [ 3, 4].
This is likely because of a developmental abnormality in the eye as a result of no CYP1B1; thus, acute or chronic inhibition of CYP1B1 in adults may not cause increased ocular pressure.
dKO mice exhibited significant developmental abnormalities in both the lung and the heart.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com