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The predominant role of T cells in CIA development was demonstrated by using anti-CD4 or anti-TCRαβ monoclonal antibodies and T cell-deficient mice [ 3, 4, 27].
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That inflammation itself can induce genetic mutation and thus predispose to neoplastic development is demonstrated by the spontaneous inflammatory bowel disease that develops in interleukin-10 deficient mice, since this is associated with a colonic mutation rate five times greater than wild-type mice, with a ten-fold increase in small deletions and insertions to DNA [ 24].
The evolutionary steps from egg laying to placental development are demonstrated by extant species.
In this paper, the principles of CAD systems design and development are demonstrated by means of two examples.
The pivotal importance of homeobox genes to animal development is demonstrated by the fact that mutation or experimental misexpression can cause dramatic developmental abnormalities or cancers [ 1- 3].
9 Indeed, the importance of sialic acids in development is demonstrated by the observation that disruption of de novo sialic acid biosynthesis in mice causes embryonic lethality.
The importance of miRNAs in skeletal muscle development is demonstrated by the fact that the muscle-specific knockout of Dicer in mice results in decreased skeletal muscle mass accompanied by abnormal myofiber morphology and perinatal death [ 47].
The role played by growth hormone in mammary development is demonstrated by the rudimentary breast development seen in growth hormone receptor knockout mice [ 8] and by the observation that acromegalic patients who have increased growth hormone levels exhibit increased risk for cancers, including breast cancer [ 9].
All the developments are demonstrated by means of a real-time fuzzy control experiment on the cantilever beam with surface-bonded piezoceramic sensors and actuators.
The grain structure development was demonstrated to be dictated by the texture evolution but also to involve {10¯12} twinning, geometrical effects of strain and limited discontinuous recrystallization.
This requires cell division to continue throughout later phases of flower development, which was demonstrated by monitoring the cell division pattern via Histone4 expression from Iberis in different petal stages.
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CEO of Professional Science Editing for Scientists @ prosciediting.com