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TRPV4 activation by mechanical stress could facilitate osteoclast development to the point that the remodeled mature bone relieves this stress.
"Lack of development" is a central property of the "under-challenged" subtype, which is characterised by feelings of indifference, boredom, and the perceived lack of personal development to the point that one is considering other occupations that might better express one's talent [ 14- 16].
Despite the current lack of a completely effective therapy for MPS III, there is much promise in therapy development, to the point that clinical trials to evaluate intrathecally-delivered ERT in MPS IIIA and gene therapy for MPS IIIA and MPS IIIB patients are in either clinical trial or being planned.
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We're forcing ourselves into a digital arrested development to the point where someone like me gets frustrated that one of the most important people in my life had the audacity to call me.
Like Raymond Queneau, Pamuk is gifted with a light, absurdist touch, spinning out farcical plot developments to the point of implying that any plot, in this indifferent and chaotic universe, is farcical.
For example, Dr. Brower said that in one region where there has always been a large monarch colony, development has encroached to the point that the once remote roosts of monarchs are now dangling in trees right next to farm fields.
This species' once wide-scale semi-arid range has been heavily disturbed by predation from feral pests (e.g. foxes and dingoes) and extensive land clearing for pasture development for livestock grazing to the point that it is threatened by extinction.
But recent developments have envenomed things to the point that Arab diplomats troop daily into the State Department to warn that the U.S. quest for détente with Tehran is dangerous.
Since the early 1980's, American development programs have been gutted, to the point that there is little institutional understanding about societies seething because of mass unemployment, rapid population growth, pervasive disease and chronic hunger.
Beijing's central planners (along with the provincial bureaucracy which subsists on lending and development fees) overbuilt the country to the point that 46% of the Chinese economy is now in "fixed investment" – infrastructure and real estate spending.
In an attempt to speed up housebuilding, council leaders have called for developers to pay council tax on unbuilt developments from the point that the original planning permission expires.
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CEO of Professional Science Editing for Scientists @ prosciediting.com