Sentence examples for development the potency from inspiring English sources

During development, the potency of stem cells is reduced over time from totipotent (morula) to pluripotent (embryonic stem cells) to multipotent (fetal and adult stem cells) to omnipotent (precursor cells) due to progressive gene silencing.

Such decoupling means that the effect of temperature on sex ratio is not perfectly predicted by current models based solely on the effect that temperature has on development, revealing that the potency that temperature has to influence developmental rate differs somewhat from its potency to induce sex determination as described below.

Because of their critical role in immunity to tumors, viruses, and intracellular parasites such as T. cruzi [ 13– 16, 23– 25], a major goal of vaccine development is to harness the potency of CD8+ T-cell responses.

Here, we discuss how strategies for the development of potency assays for TE/RM product candidates may harness potential mechanisms of action or other therapeutically relevant bioactivity along with cell number and viability.

Furthermore, additional development is required to ensure the potency of this allogeneic CAR T therapy, at least as potent as its autologous counterpart.

It should be noted, however, that the p Ka-value trend found for this class of ionizable lipids with apoE-dependent hepatic delivery may not apply to other cationic and potentially ApoE-independent delivery systems.[ 6, 12] To identify potent and safe siRNA delivery systems for clinical development, it is important that the potency in mice translates to non-human primates.

These new developments raise disturbing questions about the potency and transmissibility of the anthrax being sent through the mail.

Future work would benefit from the ability to better characterize the uncertainty surrounding model choices in the development of cancer potency factors.

Moreover, the development of alternative potency assays that are less dependent upon specific antigen-antibody interactions that could be affected by the manufacturing platform is warranted.

Continued development and new strategies are essential to improve the potency of AAV vectors and reduce the effective dose needed for clinical efficacy.

The potency testing is critical for the development of hPSC-based cell therapy products and is needed before progression to phase III clinical trials.