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In the initial stages of chemical development, the identification of the sequential processes and perturbations of biological pathways at a molecular level (e.g. molecular initiating events; MIE) through to the cellular or organ level leading to an adverse outcome provides insight into the SAR and can allow for the grouping of similar mechanisms of biological response [39].
Since this compound is moving toward clinical development, the identification of a suitable drug partner will be crucial, and it will be important to monitor the possible emergence of mutations in the pfcarl locus and particularly at position 1076.
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A crucial aspect of drug design development is the identification and characterization of novel molecular targets.
This paper focuses on the development and the identification procedure of a new model for reinforced concrete joint elements subject to earthquake loadings.
Therefore, electrochemically assisted electrospray ionization enables method development for the identification of SEL and its potential metabolites by means of HPLC/ESI-MS.
Alternative strategies for drug development involve the identification of key factors common to exacerbations induced by a range of different viruses.
That having been said, when tourism is identified locally as a component of an overall economic development strategy, the identification, protection and enhancement of the community's historic resources will be vital for a successful tourism effort.
Unlike the rationalistic PPBS approach, organization development stressed the identification of personal with organizational goals, the "self-actualization" of workers and managers, effective interpersonal communication, and broad participation in decision making.
However, an important consideration in drug development is the identification of active compounds, thus good correlations to experimental binding free energy is of more value than the rank ordering of compounds.
The initial step for the model development is the identification of a structural homology.
Subunit vaccine development requires the identification of immunogenic targets from the wide array of antigens expressed by the parasite.
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