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Thus, developing efficient mechanisms for guideline development that rely on adaptation of existing guidelines to the Estonian setting will promote the use of guidelines by involving local physicians in the process.
The choice of targets was primarily guided by our earlier assessment of the craniofacial phenotypes in the ML-II embryos, which indicated that stages of cartilage development that rely heavily on the deposition and/or remodeling of ECM proteins (such as collagens) were particularly sensitive to reduced Man-6-P biosynthesis (Flanagan-Steet et al., 2009).
Taking advantage of a zebrafish model of ML-II, we previously showed that the cartilage morphogenesis defects in this model are associated with altered chondrocyte differentiation and excessive deposition of type II collagen, indicating that aspects of development that rely on proper extracellular matrix homeostasis are sensitive to decreases in Man-6-P biosynthesis.
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Still, China has not adopted many of the reforms that economists suggest are needed to lay the groundwork for a new phase of development that relies less on exports to other countries and depends more on the spending of the Chinese themselves.
This variability poses a challenge for future vaccine development that relies on worldwide molecular epidemiologic studies.
The phases of development are laid out from the "ground up" to illustrate the cumulative aspect of knowledge development that relies on solid foundations of pre-clinical evidence and proceeds through successively more applicable clinical studies.
Several modular development frameworks have been developed that rely on attributes to share information among components.
It also encourages an approach to development that relies on continuing increases in value.
Many development groups that rely on the companies worried that the government would replace them before Afghan forces were trained or numerous enough to take on the work.
Mr. Nunn said Mr. Buffett's involvement with the initiative would be particularly valuable not only in fund-raising, but also in persuading pharmaceutical companies and other biotech concerns that it is worth investing in research and development efforts that rely on skills of former Soviet scientists.
It would also essentially compete with Facebook and Twitter — development platforms that rely on ad revenue and sometimes release new features that compete with apps created by third-party developers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com