Sentence examples for development substantial changes from inspiring English sources

However, during development, substantial changes occur in the architecture of leaf shelters that caterpillars construct.

In light of that development, substantial changes have been made in terms of policy in law enforcement.

Infection of plants by pathogens and the subsequent disease development involves substantial changes in the biochemistry and physiology of both partners.

This 'hourglass' model of developmental similarity among vertebrates suggests that, while certain stages of development undergo substantial change over evolutionary time, there exists a significant conservation of the mechanisms underlying development across vertebrates [ 6- 9].

The fact that HCN4 (Fig.  1) occurred alone throughout embryonic development, followed by substantial changes in HCN transcription after birth, caused us to examine HCN isotypes in dissected mouse hearts at P10.

Infection of plants by pathogens and the subsequent disease development are accompanied by substantial changes in the physiology of both partners.

In addition, studies in the healthy brain indicate a dual role for microglia during postnatal development associated with the substantial changes that occur in the connectivity of the CNS over this period.

During the long course of the Pacific Design Center's development, the neighborhood went though substantial changes.

They are essential for growth and metabolism throughout the life (Power et al. 2001; Liu and Chan 2002) and regulate different aspects of development including metamorphosis, which requires substantial changes in morphology, physiology, and behavior (Yamano et al. 1991; Liu and Chan 2002).

Whereas it is not yet clear how this relates to human development, the human brain undergoes substantial changes in long- and short-range myelination and connectivity in late childhood [ 22, 23, 24].

To determine those miRNA that were differentially regulated with respect to developmental age, all miRNA were ranked based on their temporal expression variance through E12 to P0. miRNA undergoing substantial changes throughout development (SD > 1.3) were selected for downstream analysis (Additional file 3).