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Sixty polar analytes were first screened to identify those most suitable for inclusion in chromatographic test mixtures; then, a multi-dimensional method development study was conducted to determine the optimal choice of stationary phase, modifier additive and temperature for the separation of such analytes using SFC.
A prospective development study was performed per IDEAL recommendations.
This service development study was approved by the Clinical Effectiveness Department at Barts Health NHS Trust (project registration number 156/12).
An outcome measure development study was performed including item generation (existing shoulder measures, focus groups) and item selection (selection criteria, importance and feasibility ratings, pilot testing, Rasch analysis).
In the studies included, no prospective development study was powered on oncologic outcome, and only two series had a follow-up >5 yr; therefore, no significant conclusion on disease control could be derived.
Further work is required to develop and validate an accurate fracture risk scoring system for use in MS. This service development study was approved by the Clinical Effectiveness Department at Barts Health NHS Trust (project registration number 156/12).
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An empirical illustration of the MVAI measure in the context of a new product development study is provided.
Specifically, we explore whether variation in treatment effects in the NCRECE professional development study is predicted by characteristics within school walls (e.g., the composition of students and teachers), as well as those outside of school walls.
The main reason for this bias is probably the outdated development of the model, and a new EuroSCORE development study is presently being performed.
The Hemophilia Growth and Development Study is funded by the National Institutes of Health, National Institute of Child Health and Human Development, R01-HD-41224.
Data for this instrument development study were collected in five Canadian cities.
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