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Several of the differentially expressed miRNAs identified here were shown to play roles in growth and development related processes in recent studies.
Furthermore, L1-CAM restriction throughout post-weaning and to adulthood developmental phase also affected stress responsiveness and cognitive functions in adulthood [77], suggesting a key role for L1-CAM in development related processes during adolescence.
Their synergistic expression and activation enhances an Oct-Sox-complex that leads to the transcription of target genes like Nanog, Kfl4, Lefty1 or Fgf4 which are know to be involved in many development related processes and in the maintenance of stem cell associated properties [32] [36].
Development related processes are enriched in genes with both increases and decreases of either H3K27me3 or DNAMe marks (Additional file 4).
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Moreover, it has an impact on immune responses and blood vessel development/angiogenesis related processes.
Enriched biological processes related to up-regulated genes included RNA related processes, differentiation and development of epidermis and ectoderm, and cell-substrate junction assembly; whereas in the case of down-regulated genes the biological processes that were enriched included IGF-like growth factor signaling, somatic stem cell maintenance and apoptosis.
Corresponding ontology terms include reproductive development, sexual reproduction, embryonic development, skeletal system development, face morphogenesis, wound healing, as well as angiogenesis related processes.
Gaussian and related processes.
Therefore, while most development efforts are directed toward sorbent development, ADA Environmental Solutions ADAA) has focused on development and demonstration of the related process and equipment.
Through an examination of the processes of drug development related to the same candidate substance in a Japanese firm and an American firm, we suggest that, in addition to organizational capabilities at the corporate level, social capital, specifically formed under a certain innovation system, plays a key role in leading to the successful introduction of breakthrough innovations.
First, the current developments related to process synthesis intensification are reviewed with a focus on process intensification.
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