Regression was defined, here as a loss of previously achieved milestones in language, personal or social development or in adaptive skills.
If expression of the gene of interest is thought to be detrimental during development or if adaptive changes during development caused by the transgenic overexpression should be avoided, gene expression should be induced only after embryonic development.
It is also conceivable that the apparent dispensability of the MMPs can be explained by enzymatic functional overlap, compensatory upregulation or adaptive development, as has been exemplified by the generation of three individual MMP double-deficient mice [38] [40] and Plau Plat double-deficient mice [16], [21].
There are no selective inhibitors of D3 activity and a transgenic approach, using cardiac-specific, conditional knock-out of D3 expression appears to be the optimal way to test the relevance of D3 activity for the development of adaptive or maladaptive ventricular remodeling.
A central goal of adaptation is the development of adaptive capacity, without which, adaptation is less likely to occur.
Analyses of complete eukaryotic genome sequences have revealed that gene duplication has been rampant, and that this process can be linked to important evolutionary transitions or major leaps in development and adaptive radiations of species (see, for example, [ 80, 81]).
In [P10], Kettunen and Laanti compare eight different software process models from which three are agile methods, namely feature-driven development, adaptive software development and XP.
T cell activation is a crucial event in the development of adaptive immune response to pathogens or tumor cells.
Molecular studies defining the role of gene or protein expression signatures in development and adaptive strategies of marine larvae in the natural marine environment are limited.
"Rather than construct a static material or one that simply changes its shape, we're proposing the development of adaptive, biomimetic composites that reprogram their shape, properties or functionality on demand, based upon external stimuli," says Balazs in the press release.
