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These data warrant further development of Wit as a novel anticancer drug for targeting tumours that harbour hyperactivated STAT3 and STAT5.
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We next determined the effect of Wit on breast tumour growth in vivo in a transgenic mouse model in which mammary tumour development is driven by ErbB2, a RTK known to activate both STAT3 and STAT5.
"Brevity," Allon replied, "is the soul of wit".
This rendering may not be the essence of wit.
He was full of wit and unusual insights.
He was a man of wit, intelligence, warmth and caring.
Celtic need more of that kind of wit and imagination.
It is the expression of the unchallenged mastery of wit.
It's full of wit and hilarious humour.
Benjamin Franklin was a perennial source of wit and wisdom.
Interestingly, dnrx and dnlg1 mutants have reduced levels of the Bone Morphogenetic Protein (BMP) receptor Wishful thinking (Wit), and Dnrx and Dnlg1 are required for proper localization and stability of Wit.
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