Sentence examples for development of variants from inspiring English sources
In the development of variants, for example, a song with four musical lines (e.g., ABCD) may lose two of these lines and take on the form ABAB. In turn, two new lines may be substituted for the initial two, giving it a form EFAB. Folk tunes also change when they cross ethnic or cultural boundaries.
The resulting adaptation is the development of variants which are not recognized by the immune system.
The first paper describes the application of a combinatorial mutagenetic approach, which resulted in the development of variants of the P AOX1 promoter of the yeast Pichia pastoris with increased expression levels and abolished glucose repression.
Mutation of MITF leads to the development of variant IIA of Waardenburg syndrome.
This clonal evolution in combination with chromosomal instability may result in the development of variant subclones within one tumour harbouring different sets of genetic changes.
In the past few years, the generation of fast, powerful, and cost-effective gene discovery and mutation detection methods, in addition to the development of variant pathogenicity assessment tools, has markedly increased the clinical utility of molecular diagnoses.
Variant-oriented manufacturing systems paradigms, as enablers of product variety, and the effective co-development of variants and their manufacturing systems to ensure economic sustainability are reviewed.
One of the limitations of targeted therapies is the development of resistant variants and these variants typically present with unique gene expression patterns and characteristics compared to the original tumor.
Pure::variants (Pure::Variants 2013) is a tool that supports the development of application variants.
With regard to copy-cutting, the recent development of Cas9 variants with broadened PAM specificity21,22 may substantially increase the fraction of alleles that can potentially be driven by this method.
The development of Cre variants that allow the recombination of true asymmetric lox mutant sites has not yet been addressed, however.
