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Development of tumor targeting pharmaceuticals on a modular platform is an attractive paradigm.
Both of aminopeptidase N (APN) and matrix metalloproteinase (MMP) are essential metallopeptidases in the development of tumor invasion and angiogenesis.
The effect of nanotubes on the development of tumor process can occur at the level of cell-to-cell interaction, with extracellular matrix and stoma structures.
It has been shown that 3-D culture most correctly reflects the effect of cellular microenvironment on the development of tumor micronode in vitro [9,10].
The synergistically collaboration of c-Met/HGF and VEGFR-2/VEGF leads to development of tumor angiogenesis and progression of various human cancers.
Intelligent drug delivery system (IDDS), which can encapsulate and transport the drug to the nidus while monitor the pharmacokinetics behavior, greatly promote the development of tumor therapy.
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His research over a period of more than 50 years has directly enabled the design and development of tumor-specific vaccines and targeted antibodies.
For development of tumor-specific chemotherapy, we designed liposomes with temperature-triggered drug release and magnetic resonance imaging (MRI) functions.
Herein we present data which provide valuable insight into the design and development of tumor-specific drug delivery systems.
The discovery of cell-surface receptors overexpressed in tumors has led to the development of tumor-targeting radiopeptides for a variety of cancers.
Importantly, the development of tumor-targeted probes for optical imaging has encouraged many researches in the last 10 years, leading to many recently published preclinical studies.
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