The researchers aim to figure out which cell types are associated with the development of tolerance so that more effective treatments can be developed.
No development of tolerance was seen clinically in these patients and the patches were well tolerated.
Tolerance to the anxiolytic/antipanic effects is controversial with some authoritative sources reporting the development of tolerance, and others reporting no development of tolerance; tolerance will however, develop to the sedative-hypnotic effects within a couple of days.
Development of tolerance and supersensitivity to phencyclidine in rats after repeated administration of phencyclidine.
Place-aversion conditioned by phencyclidine in rats: development of tolerance and pharmacological antagonism.
This action closely paralleled the development of tolerance to the stereotypy and ataxia induced by PCP (Sturgeon et al, 1982).
This preliminary study in 6 patients with chronic low back pain prospectively evaluated the development of tolerance and OIH.
We find this response to be blunted after chronic ethanol exposure (development of tolerance).
These changes explain the development of tolerance to these agents, the onset of noxious withdrawal symptoms and relentless craving for them when users try to remain abstinent.
Nω-nitro-l-arginine did not prevent the development of tolerance or withdrawal hyperexcitability in the electroshock model, while in the PTZ model inhibition of nitric synthesis prevented withdrawal hyperexcitability but had no effect on the development of tolerance.
Their role in preventing the development of tolerance to the anticonvulsant effect was seen on Days 1, 3, and 6.
