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The reproductive outcomes, decreases in circulating T4 levels, assignment of rats for different measures, general health, and development of the rats used in these studies, as well as biological relevance of the highest dose used in this study in terms of human levels, have been previously reported (Kodavanti et al. 2010).
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The present study, based on the development of the first antibody reportedly produced against rat Lot1, examines protein expression during normal development of the rat cerebellum and following methylazoxymethanol (MAM) administration, which results in hypoplasia of the cerebellar granule cell population.
We studied the anatomical development of the rat retina, by analyzing the migration of neural progenitors and the process of retinal ganglion cell death, which exerts a key role in sculpturing the developing retinal system at perinatal ages.
To our knowledge this is the first description of this kind of phenomenon in normal development of the rat and indicates that weaning period is a critical window for pancreatic development.
The first experiment was designed to study whether in utero BPA exposure affects the development of the rat mammary gland.
This transcriptomic analysis suggests relatively well established neuroprotective mechanisms at the blood-CSF barrier throughout development of the rat.
Studies on the development of the rat pancreas indicate that chronologically glucagon and somatostatin appear prior to insulin [ 38].
Following normal development of the rat heart, the FD of nuclear chromatin of cardiomyocytes diminished significantly (r = -0.603; p = 0.001; Spearman rank order correlation) with increasing age [133].
It has been shown that during postnatal development of the rat optic nerve 50% of oligodendrocytes normally die, but no astrocyte death was observed.
Therefore, our data suggest that prenatal exposure to BBP can have an effect on normal post-natal development of the rat.
The computational model used in our study is of a rat ventricle, for maximal compatibility with available experimental data for wild-type animals and the recent development of the rat as an animal model for Takotsubo cardiomyopathy (8, 20).
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