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The development of the patch required a change in form from the hydrochloride salt to free base, which enabled the drug to pass through the skin.
A key goal during the development of the patch was to minimise the occurrence of false alarms that is, when a caregiver receives a notification, but the patient's vital signs remain within the specified limits.
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The breakthrough came in the 1970s and '80s with the development of the patch-clamp technique, which enabled researchers to directly measure currents flowing across single ion channels in the membrane.
German physicist, winner with Bert Sakmann in 1991 of the Nobel Prize for Physiology or Medicine for their research into basic cell function and for the development of the patch-clamp technique, a laboratory method that can detect the very small electrical currents produced by the passage of ions through the cell membrane.
German medical doctor and research scientist who in 1991, together with German physicist Erwin Neher, won the Nobel Prize for Physiology or Medicine for research into basic cell function and for their development of the patch-clamp technique a laboratory method widely used in cell biology and neuroscience to detect electrical currents as small as a trillionth of an ampere through cell membranes.
Nascent structural correlates of future pinwheel zones may exist as "seed points" during the development of the superficial patch system, with the intriguing implication that orientation pinwheels in v1 may in fact be a consequence of patch system formation.
The range of combined hormonal contraceptive (CHC) options has increased with development of the transdermal patch and the vaginal ring.
Our patient did not have any skin lesion in the scrotum prior to the development of the necrotic patch.
Consequently, we predict that as long as the branching and axon guidance machinery is not affected, disturbance of the pattern of electrical input to the neurons will not abolish the development of the superficial patch system.
This exposition invites a great deal of further work, including development of the multi-patch (meta-population) ODEs with flight, full sensitivity analysis of the agent-based model, further "dialogue" between the two approaches, and calibration to historical cases.
To date, the distribution of exotic species in forested patches has been correlated with the type of development surrounding the patch, with those surrounded by agricultural or urban development often more highly invaded.
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