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Later on, other types of experimental evidence, based on epidemiological data of cancer mortality, allowed the development of the multistage theory (MST) of cancer development [ 15- 18].
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We will also summarize work regarding the development of a multistage drug delivery strategy, a robust carrier platform designed to overcome several biological barriers while en route to tumors.
The development of multistage models for hepatocarcinogenesis in the rodent has renewed interest in such marker alterations in preneoplastic as well as neoplastic hepatocytes.
Delay between initiation and promotion on mouse skin was in 1949 reported by Berenblum and Shubik not to affect tumour yields, and this led to the important concept of the irreversibility of initiation and stimulated the development of multistage models.
Numerous previous reports have linked B[ a]P exposure with DNA-adduct formation, which then results in genetic alterations that contribute to the development of multistage carcinogenesis.
Duo to the low permeability and porosity, economic development of the shale gas resources always needs a multistage hydraulic fracturing.
However, we offer the caveat that, because of the multistage and multifactor nature of cancer development, these analyses should be grounded on the mode of action of the specific agent or classes of agents with putatively similar modes of action.
Features of the multistage AHHP are discussed.
Some properties of the multistage system are proved.
The joy of the multistage festival experience is that it allows one to act as a curator of sorts.
Horizontal wells with multistage hydraulic stimulation are the primary production strategies during development of the unconventional tight reservoirs.
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