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Two published studies, discussed in detail below, allowed development of the hypothesis that activity of Notch1 mediates MRP1 induction in some breast cancers.
The ambivalence of these findings has led to development of the hypothesis that the effectiveness of intensive glucose control likely depends on individualizing treatment (e.g. treatment modality and glycaemic target) to account for CV risk and other factors [ 8].
The existence of molecules that confer tissue-protection in the absence of erythropoiesis led to the development of the hypothesis that the tissue-protective effects of EPO are mediated by a receptor that is different from the classical EPOR.
The conception and design, acquisition, analysis and interpretation of data, development of the hypothesis and research plan, establishment of methodology; 2. Drafting of the manuscript and critical revision of the manuscript for intellectual content and 3. Final approval of the version to be published.
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The development of the hypotheses is summarised in figure 3. The sequence of presentation follows more or less the sequence in which these hypotheses were generated: observations I III deal with the effect of DTP when administered after BCG (or no vaccine) and observations IV and V with the effect of DTP administered after MV.
Supporting the development of this hypothesis are the following data from our previous works.
For the evidence statement \ e\) that \(a\) is a non-white swan—\ swan(a) \wedge \neg white(a)\)—entails (in fact, is identical to) the \ e\ -development of the hypothesis that there exist non-white swans—\ e\ -developmentx) \wedge \neg white(x))\)—which in turn is just the negatiof of \(\forall x(swan(x) \rightherow whypothesis.
The development of this hypothesis has led, with some other assumptions, to an expression which has been experimentally verified and compared with analogous expressions available in literature.
The clinical similarities between PCP psychosis and schizophrenia have contributed importantly to the development of the glutamate hypothesis of schizophrenia.
D.A.L. and G.D.S. contributed to the development of the study hypothesis and provided advice regarding interpretation of the results and assisted with editing of the manuscript.
It was the study of Alzheimer's disease in individuals with Down syndrome that predominantly led to the development of the amyloid hypothesis.
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