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Third, suboptimal maternal thyroid function has repeatedly been associated with poor development of the foetal CNS.
The development of the foetal immune system is also influenced by the allergic state of the mother.
Increased levels of cortisol in the mother could potentially mediate such effects of depression and anxiety on the development of the foetal HPA system.
The nature of inflammation-induced neural damage is likely to be dependent both on the stage of cortical development and the stage of development of the foetal immune system at the time of the insult.
The results of the present study show that maternal inflammation has not only an immediate consequence for the development of the foetal cortex, but also a long-term effect on cortical cytoarchitecture and structure during post-natal life.
This workshop will be held in the first trimester since this is when organogenesis is produced and is therefore the time of greatest risk for the appearance of alterations in the development of the foetal central nervous system in cases of maternal iodine deficiency.
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The aetiology of Sprengel's deformity is related to limb bud formation, which results in disruption of normal sequence of development during the foetal period [1, 2].
The outcome depends upon the extent of the damage to actively dividing cells, the stage of foetal organogenesis, the development of foetal immune competence, and the ability of the foetus to mount an inflammatory response [ 10].
In 1993 it was proposed that widespread environmental man-made chemicals with agonistic or antagonistic effects on hormonal steroid receptors, in particular the estrogen receptor, might disturb the foetal development of the male gonads resulting in impaired multiplication of Sertoli cells leading to a permanent reduction of sperm counts [ 1, 2].
Effects were observed on the adrenal steroidogenesis and foetal development of the adrenal cortex.
To investigate if genes identified in this study could have a role during foetal development of the prefrontal cortex (dorsolateral prefrontal cortex, ventrolateral prefrontal cortex, anterior (rostral) cingulate (medial prefrontal) cortex), they were searched in the BrainSpan database (Allan Brain Atlas) [ 29].
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