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The development of the defect assessment argument or 'leg' of the safety case is thus critically dependent on the engineer's ability to assess the severity of defects that are either present from the start of life or which may form during service.
In addition, two of these cases had defects that were not temporally related to interferon β-1b exposure (ie, the timing of the exposure was not consistent with the development of the defect) and one had a chromosomal abnormality potentially related to advanced maternal age that was classified as having no temporal association to exposure.
Duration of exposure to propofol seems to be a crucial factor in the development of the defect of fatty acid oxidation: in a patient on a propofol infusion (4.1 6.6 mg/kg per hour) [ 38] plasma C4-carnitine species rose steadily over the period of 5 days.
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During fatigue the development of the defects was monitored with pulse phase thermography using optical excitation.
Stable configurations of the primary SrTiO3 islands occurred in parallel with the development of the defect-induced RC formations, and the geometry of these features was related to the crystallographic symmetry of the SrTiO3 (001) surface.
However, the protein product of TEX14 appears to be absent in the SA affected testis highlighting the role of this gene in development of the SA defect.
Therefore, the relationship between the accelerations on a locomotive component and the dip angles of dipped rail defects is important for monitoring the development of those defects.
These may lead to the development of a defect between the pelvic peritoneum and the vagina [ 1, 4].
Increasingly, a general theme in cancer pathophysiology is the development of a defect in the function of pro-apoptotic molecules, such as p53, that commonly prepare the cell for apoptosis whenever cell proliferation or DNA damage is induced; lack of these molecules therefore deprives the cell of a critical safety mechanism [ 1].
Figure 3 Development of the SDS (summed defect score) in the individual patients (pre-PVI versus post PVI). Figure 4 Quantitative 17-segmental analysis.
Geometric morphometrics provides a powerful means to evaluate the role of shape in the development of fusion defects of the upper lip and primary palate (Cooper and Albertson, 2008; Martínez-Abadías et al., 2012).
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