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To test this hypothesis, we analyzed the effect on gametophore development of the compounds 1- N-naphthylphthalamic acid (NPA) and naringenen (Nar), which are potent PATIs in angiosperms.
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These have provided a good theoretical basis for the research and development of the compound tray.
Our results provide a basis for development of the compound as a chemotherapeutic agent.
This SAR study also led to the development of the compound 4 which is one of the most potent and selective blockers for the DAT known today.
RH conditions should be chosen based on the information needed for development of the compound.
Vigorous rootstocks increase sylleptic branching, especially in the early development of the compound tree.
No activity for cilengitide could be demonstrated in this trial, and further development of the compound was discontinued.
10, 44 During the 1980s in the course of the development of the compound for eventual launch, Beecham investigated the properties of both the anhydrate and hemihydrate.
The unfavorable risk-benefit balance of the MMP inhibitor PG-116800 in patients with knee osteoarthritis precludes further development of the compound for this indication.
Moreover, the unexpected tolerability and the good bioavailability indicate a peculiar pharmacological behaviour and the interest for further development of the compound administered orally.
A phase I clinical trial of PF-03084014 is ongoing and the data readout should inform on patient selection and future development of the compound for CRC.
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