Sentence examples for development of the aggressive from inspiring English sources

Moreover, TSPO expression levels show a strong correlation with the development of the aggressive phenotype of different breast cancer cell lines [18], [20].

TRPC6 was shown to be required for the development of the aggressive tumor phenotype, because a knockdown of the TRPC6 inhibited the glioma growth, invasion, and angiogenesis.

Therefore, TRPC6 may have an essential role in the development of the aggressive phenotype of HNSCC and may be a promising therapeutic target in the treatment of HNSCC.

Further experiments indicated that HOXC11 upregulation is required for the pro-invasive impact of PSAP to manifest fully, suggesting that HOXC11 expression is key to development of the aggressive phenotype.

Loss of Dab2 expression may thus supply activation of the Ras pathway in breast cancer, which along with other genetic changes, leads to the development of the aggressive and basal subtype of breast cancer.

The participation of RHAMM in the development of fibromatosis, the aggressive mesenchymal tumor, has also been demonstrated [ 135].

Taken together, these data suggest that Ras/PI3K/Akt/mTOR pathway may represent an important therapeutic target for the treatment of HCC among patients with differing etiologies that lead to the development of this aggressive tumor.

Study I describes the development of the Peer Aggressive Behavior Scale (PAB-S), specifically reporting the procedures used to develop its items and evidence of content validation.

Load forecasting and transmission planning background is summarized, the theoretical and empirical aspects of the hybrid methodology described, and the assumptions, structure, data development, and results of the aggressive efficiency scenario are presented.

Reflecting the sentiments of Chiller et al. (2005) and Chinain et al. (2010), we propose an upstream approach to improving HIS in the Pacific, through the development of progressively aggressive health interventions targeted at reducing the disease burden of ciguatera.

However, and even more importantly, there was a remarkable inhibition of the development of more aggressive forms of tumor, such as high-grade dysplasia, Cis, and infiltrative cancers, which is of crucial interest.