Sentence examples for development of skin sensitization from inspiring English sources

The development of skin sensitization is associated with, and requires, the activation and clonal expansion of allergen responsive T lymphocytes and it is these cells that orchestrates the cutaneous allergic reaction.

The findings reported in this paper might impact the development of in vitro assays for assessment of skin sensitization, which is crucial in order to replace the animal models currently in use.

Browse and search tools were implemented to facilitate the exploration of skin sensitization data.

Finally, progress has been made in the characterization of skin sensitization in humans and in the clinical management of ACD.

A methodology for HRIP testing is described and general guidelines for evaluation of responses indicative of induction and elicitation of skin sensitization and skin irritation are detailed.

Assessment of skin sensitization potential is a mandatory requirement for the registration or notification of most types of chemicals and products.

This early highly localized upregulation of IL-1β lends further support to the hypothesis that this cytokine plays a key role in the initial stages of skin sensitization.

A more detailed appreciation of responses induced by chemical allergens has in turn facilitated the design of novel approaches to the toxilogical evaluation of skin sensitization.

U937 and THP-1 are currently being evaluated in pre-validation stage for prediction of skin sensitization.

For longitudinal evaluation of the development of skin test reactions a maximum of 4 tests with more than 8 weeks interval were performed for each animal and with this schedule, no sensitization was observed in the control animals (data not shown).

To reduce the occurrence of skin sensitizers, chemicals are regularly screened for their capacity to induce sensitization.