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The replicable parameterization process should be useful to the development of simulation frameworks, important to environmental policy makers to analyze different scenarios during decision making process.
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We identified two frameworks on the development of simulation models in healthcare [ 20, 21].
Emphasis is also placed on the development of a global simulation framework that aims at embedding the wave simulator into a more general stochastic environment.
Moreover, this flexibility brought by the modular conception also allows to capitalize on the previous developments by incremental update of the simulation framework and makes it sustainable in time.
Furthermore, the development of computational frameworks which allow for the simulation of experimentally derived observations represents a positive departure from what has mostly been an empirically driven field, enabling a deeper understanding of the highly complex biological mechanisms we wish to ultimately emulate.
The rest of the article is organized as follows: Section 2. describes LTE femtocells, highlighting pros and cons related to the development of this new technology and the most important open issues that justify the need of a simulation framework.
It is possible that this points to shortcomings of our simulation framework.
The schematic structure of this simulation framework is presented in Figure 1.
Therefore, the whole-cell simulation goals of SB would benefit with the development of a framework for modeling, analysis and simulation that is based on a single formalism.
The Canadian framework informed development of the frameworks in Australia and the Netherlands [ 15, 17, 80, 84].
Nonetheless, the development of joint models for toxicity and efficacy would be of substantial relevance for further advances such as integrated simulation frameworks.
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