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All authors contributed to the development of risk factor weightings.
The HAQ was designed to represent a model of patient-oriented outcome assessment and has played a major role in many diverse areas such as prediction of successful aging, inversion of the therapeutic pyramid in rheumatoid arthritis (RA), quantification of NSAID gastropathy, development of risk factor models for osteoarthrosis, and examination of mortality risks in RA.
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Some authors reported that consumption of antioxidant-rich foods and beverages has a protective role against the development of risk factors for CVD [ 6].
The elevation of these biomarkers often precedes the development of risk factors such as type 2 diabetes (5), insulin resistance (IR) (6, 7), and hypertension (7, 8).
Recently, low- and middle-income countries have experienced a rapid increase in the development of risk factors for non-communicable disease among young people.
The CARDIA study is an ongoing, multicenter, prospective cohort study investigating the role of lifestyle and other factors in the development of risk factors for cardiovascular diseases among young adults (14).
The associations of less extreme variations in maternal intake of macronutrients and micronutrients with the development of risk factors for cardiovascular disease in the offspring have also been studied.
Primordial prevention, i.e. preventing the development of risk factors, could help achieve the goals of Healthy People 2020 and AHA's 2020 Strategic Impact Goals by improving both the life expectancy and the quality of life for all Americans.
Additionally, as we have reported previously (Stanhope et al 2009), 10 weeks of fructose consumption promoted the development of risk factors for MetSyn, such as accumulation of intra-abdominal fat, dyslipidemia and insulin resistance.
Findings linking CRP to incident MetS and individual components of MetS (particularly obesity and high BP) support the theory that systemic inflammation plays a key role in development of risk factors for cardiovascular disease and cardiovascular events (2).
More recently developed statistical approaches, such as dietary patterns of maternal nutrition intake during pregnancy, may give more detailed inside in the development of risk factors for cardiovascular disease later in life.
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