Sentence examples for development of remodelling from inspiring English sources

Here we investigate the effects of γδT cell blockade on established allergic airway inflammation and development of remodelling.

Infiltrating inflammatory cells such as lymphocytes and eosinophils secrete mediators which promote the development of remodelling 24.

Regulatory T cells are also involved in regulation of allergic airway inflammation and development of remodelling 34.

In humans, activin A has been implicated in the development of remodelling in interstitial pulmonary fibrosis [ 90], as well as liver cirrhosis, wound repair and renal disease [ 24].

The data presented in the present study demonstrate for the first time that γδT cells are upregulated during chronic allergic airway disease induced both systemically and locally in the lung and have the profound ability to affect the natural resolution of chronic inflammation and influence the development of remodelling.

Prolonged OVA challenge is associated with a switch to a chronic inflammatory phenotype which promotes development of remodelling 3. To investigate the participation of γδT cells in this process, we monitored pulmonary eosinophilia following administration of the γδT cell blocking antibody during established disease.

It is increasingly evident that structural cell cell communication within the lung is central to the development of remodeling, indicating that a more integrative approach should be considered when studying molecular and cellular mechanisms of remodeling.

Weber et al. (1992) reported that the severity of cardiac fibrosis may become significantly apparent with the development of remodeling by increasing MMP activity.

It has been generally considered that chronic eosinophilic inflammation is a prerequisite for the development of remodeling, and there is some animal experimental evidence to support this [ 28].

However, in order to design efficacious anti-remodelling agents we first need a greater understanding of the molecular mechanism/s underlying the development of airway remodelling.

Therefore, this review will present an overview of the control of mRNA stability and examine how mRNA stability may play a role in the development of airway remodelling in asthma.