Several challenges remain, including finding ways of targeting these agents specifically to tumors (sparing normal cells), and the development of rationales for combining these new agents with standard therapies and for prioritizing the development of an overwhelming number of novel small molecules targeting cell cycle and apoptosis.
Indeed, the development of a rationale for universal access to health care (as a requirement of justice) has been the traditional focus of philosophical reflection on health and justice.
There is discussion of the development of the rationale for MPD, which they argue came from concerns within society about the over intervention in the terminal phases of disease and abandonment by the medical profession of the dying.
This assessment included development of a rationale and methodology for extrapolating vapor exposures prior to the availability of measurement data, analysis of existing measurement data to estimate task and job exposures during 1975-1985, and extrapolation of truck and marine job exposures before 1975.
Essential to the development of process rationales for 2D material CVD is an understanding of the underlying growth mechanisms, in particular the role of typically used process catalysts.
Nevertheless, the mTOR-independent nature of the action of lithium and its cytoprotective and autophagy- inducing properties offer the possibility for the development of treatment rationales involving simultaneous lithium and rapamycin administration (Sarkar et al., 2008).
Detailed knowledge about such synergistic interactions driving cancer and rigorous evaluation of the therapeutic benefit in appropriate in vivo models is an important prerequisite for the development of novel rationale-based combination therapies simultaneously targeting such cooperative signals.
Issues Top Management Support Role of top management - Top management's role in supporting: (i) the development of a strong rationale for Six Sigma; (ii) for setting clear objectives and, (iii) for continued Six Sigma initiatives.
Costs for editorial support of the manuscript and publication costs were covered by Grunenthal - Italy (distributor for Zalviso in Italy), who however did not have any part in the development of the study rationale, the carrying out of the study, nor writing of the paper.
