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Since leptin has neurotrophic actions on the development of projections from the ARC [19], such down-regulation may impair the normal development of those projections.
Studies on genetically hyperphagic (ob/ob) mice have demonstrated a neurotrophic role for leptin in the development of projections from the arcuate nucleus (ARC) to the hypothalamic paraventricular (PVH) nucleus [19].
Within the auditory system, the lack of typical experience imposed by deafness results in a failure of proper development of projections from secondary back to primary auditory areas, which weakens important feedback loops (Sharma et al., 2009 a ).
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For both the tenability and further development of these projections, it is important to evaluate the accuracy of workforce projections.
It is not clear what aspects of retinal activity patterns may be involved in the normal development of retinogeniculate projections (for review see [27]).
Here, we describe that a precise temporo-spatial expression of Wnt5a accompanies the development of nigrostriatal projections by VM DA neurons.
The developmental history of tectal organization is also of interest; in fact, frogs and fishes were the early model animals for the study of the development of retinotectal projections (eg. refs. [11] [14]).
Implementing a subset of these guidelines will facilitate development of unbiased projections of future risk of cancer or other adverse health outcomes.
Drosophila hb9 specifies subsets of somato-motor neurons and interneurons and is required for the development of their projections.
It is thus highly likely that DZN, like chlorpyrifos (Axelrad et al. 2003; Das and Barone 1999; Howard et al. 2005), compromises the development of neuronal projections.
This result suggests that unlike RET signaling in the peripheral branches of RA mechanoreceptors, cis activation of RET by GFRa2 and NRTN may be dispensable for the normal development of central projections of RA mechanoreceptors.
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