Sentence examples for development of plague from inspiring English sources

This finding might imply that Y. pestis nlpD is required for an activity specific to the development of plague disease.

Complementation of the dapAX mutation in vivo required the introduction of both genes in trans, either in single or multiple copy, and this restored the development of plague to near wild type levels.

The cynomolgus macaque pneumonic plague model is considered standard for testing the development of plague vaccines and therapeutics.

Development of plague vaccines based on the expression of protective antigens of Y. pestis in live carriers began in parallel with the testing of subunit vaccines.

These vaccines were found to elicit the prompt (over several days) development of plague immunity against both bubonic and pneumonic forms of plague that correlated with the ability of bacteria to colonize and temporarily proliferate in tissues and organs of the mammalian host.

We therefore used this model system to study the involvement of our genes of interest in development of pneumonic plague.

Histopathology of moribund mice indicated development of bubonic plague as lymph nodes taken from subcutaneously challenged mice on day 4 post-infection showed severe hemorrhage and necrosis similar to wild type (Figure 6).

The 10 kb pPst (pesticin) or pPCP plasmid encodes plasminogen activator (Pla), a protein that is critical to the establishment of systemic infection from a peripheral site and is also thought to have an essential role in the development of pneumonic plague [13] [17].

The development of safe plague vaccines based on anti-idiotype antibodies (anti-id-ab) that bear an 'internal image' of some Y. pestis antigens with high immunogenic activity but lacking toxicity, so-called 'plague anti-idiotypic vaccine' has been reported.

All infected animals were observed over a 15-day period for the development of signs of plague infection.

Since the role of Y. pestis YopJ in the development of primary pneumonic plague has not yet been examined, we first compared the virulence of Kim53ΔJ to that of wild-type Kim53 using intranasal (i.n).n