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The younger individuals may in fact have abnormal immune regulation that predisposes to SLE-like disease while older persons may develop autoreactivity as part of aging immune responses that do not lead to development of pathology.
These data imply a central role for extracellular tau aggregates in the development of pathology.
It is important to investigate connections and pathways whose interactions might be disrupted and therefore alter collagen structure and lead to the development of pathology.
The specific aims were to evaluate the angular and positional clinical changes in the mandibular third molars over time and correlate with the development of pathology.
Experimental Lyme arthritis provides a mouse model for exploring the development of pathology following infection of C3H mice with Borrelia burgdorferi.
Magnetic resonance imaging (MRI) is uniquely suited to image articular tissues, including cartilage, menisci, and ligaments, and can thus provide greater insight into the development of pathology in the whole joint (Peterfy et al. 2004).
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Technostress, bullying, burn-out, and work-addiction are not diseases but psychosocial risk factors, that can potentially lead to the development of pathologies.
Inadequate levels of hip passive joint stiffness have been associated with the occurrence of movement dysfunction, development of pathologies and reduction in performance.
It provides direct information exposure to certain dietary factors as related to the development of pathologies in everyday life.
Therefore alteration of nuclear shuttling of secreted molecules and cell surface receptors may result in the development of pathologies of cell proliferation.
However, a number of other mechanisms in addition to melatonin suppression can be involved into the process of development of pathologies at the constant illumination.
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