Sentence examples for development of orphan from inspiring English sources
The authors' opinion article indicates one of the great barriers to the development of orphan products has been the financial risk of developing a product for a disease with very small patient populations of potential users.
To this end, a robust, small sample, exploratory analysis of Dutch multi-actor development of orphan drugs was performed.
The large costs associated with modern drug discovery mean that governments and regulatory bodies need to provide economic incentives to promote the development of orphan drugs (i.e., medicinal products that are designed to treat rare disease that affect only small numbers of patients).
These medical conditions are normally referred to as rare diseases and there is much current interest in the development of orphan drugs for the treatment of such diseases [2 4].
The EU provides a range of incentives to encourage the development of orphan drugs, the most important of which is a high level of market exclusivity: once a medicine has been awarded an orphan drug authorisation by the European Commission, no similar medicinal product can be brought to the European market for a period of ten years.
Regulations create special incentives for the development of orphan drugs to encourage new treatments for rare conditions, but public policy has largely neglected the issue of massive price increases for these drugs once they are no longer new.
Recommendations Zimbabwe should strengthen the provision of basic services, since these services are key to the survival and development of orphans and other vulnerable children.
Nevertheless, this analysis offers new insight into the relationship between psychosocial factors, exposure to adverse childhood experiences, resource constraints and the cognitive development of orphans in wide variety of contexts and diverse settings in Southeast Asia and sub-Saharan Africa.
The study explores the act's effect on financial returns to innovation and on the strategy of orphan drug development.
We need to consider other critical factors for the success of the development of an orphan drug.
