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As a result of our study we found the predicted, significant influence of the maternal nutrition on the development of offspring in their later life.
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These findings suggest that a HE gestational diet can play a critical role in the development of offspring's vascular function, predisposing them to endothelial dysfunction.
In most cases, psychosocial risk factors present during pregnancy will not disappear after delivery and might influence the parent-child relationship, affecting the healthy development of the offspring in the long term.
Both maternal 25-hydroxyvitamin D (25(OH D) concentrations during pregnancy and placental amino acid transporter gene expression have been associated with development of the offspring in terms of body composition and bone structure.
Here is a scenario, then, where a stressor experienced by one animal (the mother) influences brain development of the offspring in a sex-dependent manner and does so via effects on a tissue that is outside of the "body proper" and neither entirely fetal nor maternal!
Here, we review 34 studies in rodents linking the availability of choline during gestation and perinatal development to neurological function or performance of offspring in cognitive and behavioral tests.
Typical rodents have relatively short gestation periods (18-21 days), giving birth to large litters of offspring in which development of major organs, including the kidney, is incomplete at birth and continues well into the neonatal period.
Indeed, there is strong evidence that depression per se can adversely affect the neurodevelopment and emotional development of the offspring through in utero biological programming of fetus development and of maternal caregiving behavior (Glover 2011; Pawlby et al. 2011).
One recently developed model allows the link between maternal immune activation (MIA) and the later development of schizophrenia in offspring to be investigated while separating immune activation from maternal infection [ 20].
In this study, a positive association was found between exposure to high levels of perinatal anxiety and development of RTIs in offspring during the first year of life.
A number of experimental animal models using a range of dietary approaches have provided detailed evidence linking a maternal obesogenic environment and the development of NAFLD in offspring.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com