Sentence examples for development of numerous types from inspiring English sources
Excessive signaling from the Wnt pathways has been implicated in the development of numerous types of cancers (MacDonald et al., 2009; von Maltzahn et al., 2012).
Deregulated expression of HER2 has been implicated in the development of numerous types of human cancers [5].
Deregulated expression of ERBB molecules, namely ERBB2, has been implicated in the development of numerous types of tumours, including gastric tumours.
Of note, the ChIP data for Twi, Tin and Mef2 used in this study are not specific solely for cardiac cell types; these TFs are broadly expressed throughout the mesoderm, are involved in the development of numerous types of muscles, and thus bind to a wide range of mesodermal/muscle enhancers.
Overactivation of EGFR gives rise to the deregulation of this EGFR-dependent signaling network, which is involved in the development and malignancy of numerous types of human cancers including breast, head and neck, lung, bladder, colon, prostate, kidney, ovary, brain, and pancreatic cancers (Kolibaba and Druker 1997).
Despite the availability of numerous types of wound dressings, there is still a high demand for the development of more effective and affordable ones.
It is also a key signalling factor within the canonical Wnt pathway [ 10], which is involved in growth and development of numerous cell types [ 23].
Among the four signature genes linked to SRF, Gro2 is a chemokine and an oncoprotein, Desmin an intermediate filament involved in muscle contraction and cytoskeleton organization, DLK a transmembrane protein is implicated in development of numerous cell types such as adipocytes, skeletal and neural systems and MLC2 is a myosin component involved in development of heart and muscle.
It is of note that this same transcription factor has been shown to be crucial in the development of numerous secretory cell types in mammals, including goblet cells and clara cells in the lung, and enteroendocrine cells in the gut (Besnard et al., 2004; Gao et al., 2010; Ye and Kaestner, 2009).
The Wnt signaling is crucial for the proper development of numerous cell and tissue types, as well as for maintenance of adult stem cell populations [144].
