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Privileged structures bind to multiple receptors with high affinity, thus aiding the development of novel biologically active compounds.
The current drug design trend is to club two or three heterocyclic molecules having different sites of action to serve as a new scaffold towards the development of novel biologically active agents [17].
Prior to the development of novel biologically based therapies for multiple myeloma, relapses after successive treatment regimens resulted in progressively shorter response durations [ 1], which in part reflected the occurrence of drug resistance.
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The development of novel, biologically-based gene selection approaches may help to find these genes.
Improved scientific understanding of the biological characteristics of poorly responsive subgroups will facilitate the design of novel biologically rational combinations.
Several marine environments can provide a rich source of novel biologically active compounds.
Marine natural products have played an important role in the discovery of novel biologically active compounds.
Today, a state of the art drug discovery program often begins with screening campaigns aiming at the identification of novel biologically active molecules.
This example of natural combinatorial biosynthesis indicates the ability to produce unnatural compounds from alkaloid biosynthetic pathways, enabling the production of novel biologically active compounds.
Of equal significance is the P450scc-mediated generation of novel biologically active hydroxy-derivatives of vitamins D3 and D2.
To our knowledge, none of these studies has yet resulted in the isolation and characterization of novel biologically active chitinases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com