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Ms Fisher's problem is quite different to the development of nodules on the vocal cords.
The development of nodules relies on a continuous molecular dialogue between the two symbionts and successive steps lead to the completion of nodule formation [1], [2].
Legumes encode all functions necessary for nodule development, as demonstrated by the spontaneous development of nodules in certain legume mutants grown axenically [1], [2].
Besides changes in organic acid metabolism, changes in lipid metabolism were also noticed during development of nodules.
Western blotting analysis showed a de novo synthesis of LOXs isoenzymes in response to wounding and during development of nodules.
Dupuytren's contracture (DC) is a progressive fibroproliferative disorder characterized by development of nodules and collagen cords within the palmar fascia of the hand.
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DOI: http://dx.doi.org/10.7554/eLife.03891.007 To establish whether the development of nodule-like structures was associated with nodulation-related gene activation, we analysed the expression behaviour of marker genes induced during root nodule symbiosis (NIN and SbtS; Kistner et al., 2005) via quantitative real-time PCR (qRT-PCR; Figure 2A).
These results indicated that MYB genes may be important in the evolutional development of nodule in legumes.
Although nodules of different age were analyzed in this and the previous study [ 49], we found that dnf5-2 similarsimilar defects in development of nodule zones as it was observed in dnf5-1 nodules [ 49].
Our newly developed model resulted in the consistent development of metastatic nodules within brain parenchyma, an effect that was highly potentiated by pre-exposure to individual PCB congeners, especially PCB118.
Tuberous sclerosis nodules were detected in one fetus [ 12], suggesting that fetal development of subependymal nodules can lead to the early onset of epilepsy that was diagnosed at the age of 14 months in a neuropathologically examined autistic male.
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