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How these mutations cause the phenotype is not known, but it was hypothesized that ankyrin G mutations may lead to the abnormal development of neurons and affect neuronal excitability through altered ion channel function (33).
It has been reported to have a role as an antagonist of Wnt signaling pathway which may influence the development of neurons in dorsal midbrain [ 46], suggesting again a link between neuronal plasticity and estrous behavior.
Experts found that the chemicals "may adversely affect the development of neurons and brain structures associated with functions such as learning and memory," an EFSA statement said.
The effect of apoE4 itself on the development of neurons from the central nervous system (CNS), however, has not been well characterized.
Understanding the structural and functional development of neurons in networks has a high impact to estimate the potentials for restorative therapies.
This gene came into sight when it was discovered to function in the synaptic development of neurons such as plasticity, polarization and targeting (Borrell et al., 1999; Matsuki et al., 2010; Rogers et al., 2011).
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Examples include the development of neuron theory by Cajal on the basis of characterisation of the neuronal architecture of the brain using the Golgi method, and support for chemical transmission through resolution of the synaptic cleft by EM.
It is one of the areas which has contributed to the development of neuron-based techniques to provide solutions for disease prediction, communication, and control [2, 3, 4].
Regardless of the mechanism, the neuron nanowire couples may be advantageous for the development of neuron devices in terms of signal transfer and electronic coupling, since the clefts pose critical problems in relation to signal transfer and electronic coupling strength.
For example, tubulin isotype expression patterns change during the development and maturation of neurons [ 14, 20].
This pattern of expression suggests that MeCP2 is involved in the maturation of existing neurons rather than the development of new neurons from precursor cells.
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