Sentence examples for development of mutations from inspiring English sources

It is suggested that incorrectly repaired DNA damage may be lethal in terms of cellular reproduction and also may initiate the development of mutations or transformations in surviving cells.

Few studies have examined the temporal relationship between the development of mutations and CN-LO H CN-LO H

This is attributed, in 40%to50%0% of cases, to the development of mutations in the Bcr-Abl tyrosine kinase domain that impair imatinib binding.

Ten HBV genotypes with some subgenotypes have been described differing by geographic distribution, course of disease, response to treatment and development of mutations.

They have been shown to differ according to the course of disease, development of mutations, and response to antiviral therapy [ 26– 28].

Hence, the development of mutations in cells is both a natural and artificial - for example, in the case of smoking - process.

This broad genetic heterogeneity of disease impacting a wide range of photoreceptor functions renders the design of gene-specific therapies for photoreceptor degeneration impractical and necessitates the development of mutation-independent treatments to slow photoreceptor cell death.

Suggested hypotheses: Students should propose ideas related to the development of mutation in protease over time that would decrease the affinity of the protease inhibitor yet still ensuring the enzyme works.

This has led to the development of mutation screens based on arrayed primer extension technology, which enable the simultaneous detection of multiple mutations from one individual.

The results highlight the need for development of mutation assessment pipelines that go beyond these algorithms, particularly when evaluating homozygous nsSNPs of non-Caucasian genomes.

This large, well-phenotyped and genotyped case series is an invaluable resource for the development of mutation-specific and/or gene-specific therapies, and for future clinical trials.