Sentence examples for development of multistage from inspiring English sources

The development of multistage models for hepatocarcinogenesis in the rodent has renewed interest in such marker alterations in preneoplastic as well as neoplastic hepatocytes.

Numerous previous reports have linked B[ a]P exposure with DNA-adduct formation, which then results in genetic alterations that contribute to the development of multistage carcinogenesis.

Delay between initiation and promotion on mouse skin was in 1949 reported by Berenblum and Shubik not to affect tumour yields, and this led to the important concept of the irreversibility of initiation and stimulated the development of multistage models.

We will also summarize work regarding the development of a multistage drug delivery strategy, a robust carrier platform designed to overcome several biological barriers while en route to tumors.

Later on, other types of experimental evidence, based on epidemiological data of cancer mortality, allowed the development of the multistage theory (MST) of cancer development [ 15- 18].

Developments in the scheme of multistage evaporation and preferred evaporator design over the recent decades are reviewed.

Rip1-Tag2 mice display a reproducible pattern of multistage tumor development, from normal islets to hyperplastic/dysplastic islets, to angiogenic islets, to varying grades of solid tumor, with a well-defined angiogenic progression [ 27].

The development of NPC is a multistage process, depending on spatial and temporal control of gene expression.

This process, known as angiogenesis, is induced early during the multistage development of invasive cancers and has long been recognized as one of the important integral hallmarks of cancer [ 3].

No clear difference in IGF-IR cell expression between early and late KS stages was observed, suggesting a constant IGF-IR expression during characteristic multistage development of KS tumours.

This, together with the recent observation (Sozzi et al, 1997a, Sozzi et al, 1997b) that there is more FHIT allelic loss in carcinomas from smokers than from nonsmokers, strengthens the case for its involvement in the multistage development of lung cancer.