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In this review we firstly provide an overview of the arrival and development of microarray technology.
The development of microarray SNP genotyping has led to the genome-wide association study era of the new millennium.
The rapid breakthrough and development of microarray and sequencing technologies is probably the main tool for paving the way toward "individualized biomarker-driven cancer therapy" or "personalized medicine".
The advent of complete genomic sequences of over 800 organisms (including the human, mouse, and zebra fish genomes), and the development of microarray technology have revolutionized molecular biology.
Significant developments in molecular biology, including the sequencing of the genome, the cataloguing of genetic variation and the development of microarray techniques, enable analysis of many genotypes simultaneously.
The concomitant development of microarray technology for comparative genome hybridization studies of a large set of different meningococcal isolates as well as strains from other Neisseria species has extended our understanding of meningococcal population genetics on a genome-wide scale thus bridging the gap between meningococcal epidemiology and genomics.
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In parallel with the development of microarray-based prognostic signatures, Paik and colleagues [ 52] developed Oncotype DX, a qRT-PCR-based analysis of 21 genes (16 cancer-related and 5 reference genes), which can be used for risk stratification of ER-positive, node-negative breast cancers from patients treated with adjuvant tamoxifen.
Development of microarrays has revolutionized gene expression analysis and molecular diagnosis through miniaturization and the multiparametric features.
The development of microarray-based genetic tests for diseases that are caused by known mutations is becoming increasingly important.
The development of microarrays has allowed copy number analysis of the genome at a much finer resolution than was possible by cytogenetic analysis.
However, the development of microarrays for emerging model plants has enabled global studies elsewhere in the angiosperm tree, e.g., in the eudicot Gerbera hybrida [11], [12] and, most recently, the basal angiosperm Persea americana [8].
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