Sentence examples for development of mcc from inspiring English sources

However, the link with solar exposure remains unknown, as the precise mechanism and steps involved between time of infection by MCPyV and the development of MCC.

However, the precise mechanism and steps involved between time of infection by MCPyV and the development of MCC, as the impact of solar exposure remain unknown.

Our results strongly suggest that MCPyV is an oncogenic polyomavirus in humans, and is potentially causally related to the development of MCC but not to the morphological similar SCLC.

As the viral DNA seems to be able to integrate into the host genome, as was evidenced by Feng et al. and suggested by us, based on our finding of the MCPyV positive metastasis in one patient, a causal relationship between MCPyV infection and the development of MCC is realistic.

The time from the patient first reporting pain, which in retrospect was probably because of the development of MCC, to the confirmation of MCC was 90 days (interquartile (IQ) range: 37 205).

Furthermore, MCPyV infection is ubiquitous whereas the development of MCCs is unusual [ 9, 10].

A reasonable hypothesis to explain the association between MCC and CLL is immunosuppression related to CLL and/or to its treatments, which may favour development of MCCs, possibly through MCPyV infection.

DOI: http://dx.doi.org/10.7554/eLife.01439.026 In addition to Rfx2, recent work has identified keys roles for the transcription factors Mcidas and Foxj1 in the development of MCCs (You et al., 2004; Stubbs et al., 2008, 2012).

Figure 9 OLR maps showing the temporal development of a MCC (blue colored) region near JRO on 28-29 August 2012. 28-29 August 2012

Development of metastatic MCC occurs in >30% of patients, however, options for treating metastatic disease are limited and unsatisfactory.

The creation of the B16/LT tumor model is both necessary and important for the development of anti-MCC immunotherapy.